Lessons Learned: HIV Points tie Way Towards Precision Treatment of Mixed-Lineage Leukemia

0463946 - ÚOCHB 2017 RIV GB eng J - Journal Article
Čermáková, Kateřina - Weydert, C. - Christ, F. - De Rijck, J. - Debyser, Z.
Lessons Learned: HIV Points tie Way Towards Precision Treatment of Mixed-Lineage Leukemia.
Trends in Pharmacological Sciences. Roč. 37, č. 8 (2016), s. 660-671. ISSN 0165-6147. E-ISSN 1873-3735
R&D Projects: GA ČR(CZ) GA16-06357S; GA MŠMT(CZ) LK11205
Institutional support: RVO:61388963
Keywords : human immunodeficiency virus * transcriptional coactivator p75 * acute lymphoblastic leukemia
Subject RIV: CE - Biochemistry
Impact factor: 12.797, year: 2016

Protein-protein interactions are involved in most if not all pathogenic and pathophysiological processes and represent attractive therapeutic targets. Extensive biological and clinical research efforts have led to the identification and validation of several cellular hubs that are crucially involved in disease pathogenesis. An interesting example of such a hub is the lens epithelium derived growth factor (LEDGF/p75), a protein that tethers multiple unrelated proteins and protein complexes to the chromatin. Its chromatin-tethering ability is linked to at least two unrelated diseases-HIV infection and MLL-rearranged acute leukemia. In this review we discuss recent progress in our understanding of the interaction of LEDGF/p75 with its binding partners and focus on the first steps towards therapies targeting protein-protein interactions of LEDGF/p75.
Permanent Link: http://hdl.handle.net/11104/0263023