Study of TiO2 Nanoparticle Generation for Follow-up Inhalation Experiments with Laboratory Animals.

0463828 - ÚCHP 2017 RIV US eng J - Journal Article
Moravec, Pavel - Schwarz, Jaroslav - Vodička, Petr - Koštejn, Martin
Study of TiO2 Nanoparticle Generation for Follow-up Inhalation Experiments with Laboratory Animals.
Aerosol Science and Technology. Roč. 50, č. 10 (2016), s. 1068-1076. ISSN 0278-6826. E-ISSN 1521-7388
R&D Projects: GA ČR(CZ) GBP503/12/G147
Institutional support: RVO:67985858
Keywords : chemical-vapor-deposition * fine particles * precursors
Subject RIV: CF - Physical ; Theoretical Chemistry
Impact factor: 1.926, year: 2016

A method of long-lasting TiO2 nanoparticle generation was tested for use in follow-up studies of the health impacts of nanoparticles on laboratory animals during several weeks’ long exposure experiments. Nanoparticles were synthesized in an externally heated tube reactor by pyrolysis and oxidation of titanium tetraisopropoxide. Particle production was studied under varying reactor temperature, reactor flow rate, and precursor vapor pressure. A total of 264 h of particle generation were performed in four experimental campaigns using one batch of precursor without an observable decrease of particle production. As a result, particle production with number concentrations high above 1.0 £ 107 #/cm3 and with primary particle sizes well below 50 nm could be achieved in most of the investigated experimental conditions. Maximum of particle mass concentration reached the value 9500 mg/m3, which corresponds with emission rate 29 mg/min. The dependence of nanoparticle production and characteristics on experimental conditions was evaluated and the most suitable parameters for exposure experiments were specified. A comparison of the results with data from the literature shows that the material of the reactor plays a significant role in the process of particle formation.
Permanent Link: http://hdl.handle.net/11104/0264575