Macromolecular systems for vaccine delivery

0463724 - ÚMCH 2017 RIV CZ eng J - Journal Article
Mužíková, Gabriela - Laga, Richard
Macromolecular systems for vaccine delivery.
Physiological Research. Roč. 65, Suppl. 2 (2016), S203-S216. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA MŠMT(CZ) LQ1604
Institutional support: RVO:61389013
Keywords : vaccine delivery * cellular and humoral immunity * polymer immunostimulants
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 1.461, year: 2016
http://www.biomed.cas.cz/physiolres/pdf/65%20Suppl%202/65_S203.pdf

Vaccines have helped considerably in eliminating some lifethreatening infectious diseases in past two hundred years. Recently, human medicine has focused on vaccination against some of the world’s most common infectious diseases (AIDS, malaria, tuberculosis, etc.), and vaccination is also gaining popularity in the treatment of cancer or autoimmune diseases. The major limitation of current vaccines lies in their poor ability to generate a sufficient level of protective antibodies and T cell responses against diseases such as HIV, malaria, tuberculosis and cancers. Among the promising vaccination systems that could improve the potency of weakly immunogenic vaccines belong macromolecular carriers (water soluble polymers, polymer particels, micelles, gels etc.) conjugated with antigens and immunistumulatory molecules. The size, architecture, and the composition of the high molecular-weight carrier can significantly improve the vaccine efficiency. This review includes the most recently developed (bio)polymer-based vaccines reported in the literature.
Permanent Link: http://hdl.handle.net/11104/0264461