Parasite Cathepsin D-Like Peptidases and Their Relevance as Therapeutic Targets

0463316 - BC 2017 RIV GB eng J - Journal Article
Sojka, Daniel - Hartmann, David - Bartošová-Sojková, Pavla - Dvořák, Jan
Parasite Cathepsin D-Like Peptidases and Their Relevance as Therapeutic Targets.
Trends in Parasitology. Roč. 32, č. 9 (2016), s. 708-723. ISSN 1471-4922. E-ISSN 1471-5007
R&D Projects: GA ČR GA14-33693S; GA ČR GA13-11043S; GA ČR(CZ) GAP302/11/1481
EU Projects: European Commission(XE) 248642 - SCHISTOSOMA PROTEASE
Institutional support: RVO:60077344 ; RVO:68378050
Keywords : aspartic peptidases * cathepsin D * hemoglobinolysis * parasites * vectors
Subject RIV: GJ - Animal Vermins ; Diseases, Veterinary Medicine
Impact factor: 6.333, year: 2016

Inhibition of aspartic cathepsin D-like peptidases (APDs) has been often discussed as an antiparasite intervention strategy. APDs have been considered as virulence factors of Trypanosoma cruzi and Leishmania spp., and have been demonstrated to have important roles in protein trafficking mechanisms of apicomplexan parasites. APDs also initiate blood digestion as components of multienzyme proteolytic complexes in malaria, platyhelminths, nematodes, and ticks. Increasing DNA and RNA sequencing data indicate that parasites express multiple APD isoenzymes of various functions that can now be specifically evaluated using new functional-genomic and biochemical tools, from which we can further assess the potential of APDs as targets for novel effective intervention strategies against parasitic diseases that still pose an alarming threat to mankind.
Permanent Link: http://hdl.handle.net/11104/0262535