0462923 - MBÚ 2017 RIV CH eng J - Journal Article
Biler, M. - Trouillas, P. - Biedermann, David - Křen, Vladimír - Kubala, M.
Tunable optical properties of silymarin flavonolignans.
Journal of Photochemistry and Photobiology A-Chemistry. Roč. 328, SEP (2016), s. 154-162. ISSN 1010-6030. E-ISSN 1873-2666
R&D Projects: GA MŠMT(CZ) LD15084
Institutional support: RVO:61388971
Keywords : Silymarin * Flavonolignans * UV/Vis absorption
Subject RIV: CF - Physical ; Theoretical Chemistry
Impact factor: 2.625, year: 2016

Exposure to UV radiation leads to several skin disorders. In particular, this can be attributed to an increase of the rate of DNA mutations, either due to direct absorption by proteins and DNA (mainly UVB), or due to ROS generation (mainly UVA). The plant extract silymarin is a promising sunscreen agent. It contains numerous flavonolignans and other polyphenol derivatives. In this joint experimental and theoretical study, we focus on silybin (SB), silychristin (SCH), silydianin (SD), and their 2,3-dehydroderivatives (DHSB, DHSCH, DHSD) and we describe their UV/Vis absorption properties, particularly the pH-dependence. Under acidic conditions, SB, SCH and SD exhibit a main and a minor absorption band in the UVB and UVA regions, respectively. The deprotonation in basic environment reverses this trend, making the UVA-absorption band predominant.
Permanent Link: http://hdl.handle.net/11104/0262278