0462458 - ÚCHP 2017 CZ eng C - Conference Paper (international conference)
Majerová, D. - Tran, D.T. - Kulaviak, Lukáš - Růžička, Marek - Štěpánek, F. - Zámostný, P.
Effect of Colloidal Silica Dioxide on Rheological Properties of Common Pharmaceutical Excipients.
Abstracts. -: -, 2016, F4.3. ISBN N.
[International Conference on Process Integration, Modeling and Optimization for Energy Savings and Pollution Reduction (PRES) /19./. Prague (CZ), 27.08.2016-31.08.2016]
Institutional support: RVO:67985858
Keywords : rheological properties * pharmaceutical excipients * comparison
Subject RIV: CI - Industrial Chemistry, Chemical Engineering

In this work, the rheological properties of silicified microcrystalline cellulose and pregelatinized starch was investigated in comparison to the characteristics of pure excipients. At first, pure materials were analysed on scanning electron microscopy (SEM) to obtain their particle size distribution and particle shape. Also the rheological properties of all three substances were examined by the Freeman FT4 rheometer. The observed properties were in accordance with known characteristics and typical behaviour of the excipients.
Permanent Link: http://hdl.handle.net/11104/0261924