Breath concentration of acetic acid vapour is elevated in patients with cystic fibrosis

0462179 - ÚFCH JH 2017 RIV GB eng J - Journal Article
Smith, D. - Sovová, Kristýna - Dryahina, Kseniya - Doušová, T. - Dřevínek, P. - Španěl, Patrik
Breath concentration of acetic acid vapour is elevated in patients with cystic fibrosis.
Journal of Breath Research. Roč. 10, č. 2 (2016), s. 021002. ISSN 1752-7155. E-ISSN 1752-7163
R&D Projects: GA ČR(CZ) GA14-14534S
Institutional support: RVO:61388955
Keywords : cystic fibrosis * SIFT-MS * acetic acid
Subject RIV: CF - Physical ; Theoretical Chemistry
Impact factor: 4.318, year: 2016

A study has been carried out of the volatile organic compounds present in the exhaled breath of 58 cystic fibrosis (CF) patients. An important observation is that the acetic acid vapour concentration measured by selected ion flow tube mass spectrometry (SIFT-MS) is significantly elevated in the exhaled breath of CF patients, independent of the Pseudomonas aeruginosa (PA) infection status (PA-infected median 170 ppbv; PA-negative median 182 ppbv), compared to that of healthy controls (median 48 ppbv). The cause for this may be decreased pH of the mucus lining the CF airways. Thus, we speculate that non-invasive measurement of breath acetic acid concentration could serve as an indicator of the acidity of the CF airways mucosa. © 2016 IOP Publishing Ltd.
Permanent Link: http://hdl.handle.net/11104/0261677