[(eta(6)-p-cymene)Ru(H2O)(3)](2+) binding capability of aminohydroxamates - A solution and solid state study

0461986 - BFÚ 2017 RIV US eng J - Journal Article
Parajdi-Losonczi, P.L. - Benyei, A.C. - Kovats, E. - Timari, I. - Muchová, T. - Novohradský, Vojtěch - Kašpárková, Jana - Buglyo, P.
[(eta(6)-p-cymene)Ru(H2O)(3)](2+) binding capability of aminohydroxamates - A solution and solid state study.
Journal of Inorganic Biochemistry. Roč. 160, JUL2016 (2016), s. 236-245. ISSN 0162-0134. E-ISSN 1873-3344
R&D Projects: GA MŠMT(CZ) LH14317
Institutional support: RVO:68081707
Keywords : Ruthenium complexes * Aminohydroxamates * Anticancer
Subject RIV: BO - Biophysics
Impact factor: 3.348, year: 2016

Complex forming capabilities of [(eta(6)-p-cymene)Ru(H2O)(3)](2+) with aminohydroxamates (2-amino-N-hydroxyacetamide (alpha-alahaH), 3-amino-N-hydroxypropanamide (beta-alahaH) and 4-amino-N-hydroxybutanamide (gamma-abhaH)) having the primary amino group in different chelatable position to the hydroxamic function were studied by pH-potentiometry, NMR and MS methods. Formation of stable [O,O] and mixed [O,O][N,N] chelated mono- and dinuclear species is detected in partially slow with alpha-alahaH and beta-alahaH or in fast processes with gamma-abhaH and the formation constants of the complexes present in aqueous solution are reported. Synthesis, spectral (NMR, IR) and ESI mass spectrometric characterization of novel dinuclear alpha-alaninehydroximato complexes containing the half-sandwich type Ru(II) core is described. The crystal and molecular structure of [{(eta(6)-p-cymene)Ru)(2)(mu(2)-alpha-alahaH(-1))(H2O)Br]Br center dot H2O (1) and [(eta(6)-p-cymene)Ru)(2)(mu(2)-alpha-alahaH(-1))(H2O)Cl]BF4 center dot H2O (2) was determined by single crystal X-ray diffraction method.
Permanent Link: http://hdl.handle.net/11104/0261527