Nuclear track-based biosensing: an overview

0460311 - ÚJF 2017 RIV GB eng J - Journal Article
Fink, Dietmar - Hernandez, G. M. - Arellano, H. G. - Vacík, Jiří - Havránek, Vladimír - Hnatowicz, Vladimír - Kiv, A. - Alfonta, L.
Nuclear track-based biosensing: an overview.
Radiation Effects and Defects in Solids. Roč. 171, 1-2 (2016), s. 173-185. ISSN 1042-0150. E-ISSN 1029-4953
R&D Projects: GA ČR(CZ) GBP108/12/G108; GA MŠMT LM2015056
Institutional support: RVO:61389005
Keywords : swift heavy ions * polymers * irradiation * ion tracks * etching * nanopores * enzymes * biosensors * biotechnology
Subject RIV: EI - Biotechnology ; Bionics
Impact factor: 0.443, year: 2016

An overview on the development of biosensors based on nuclear tracks in solids is presented. A few decades ago it was found that nuclear tracks in solids can be usefully applied for the creation of biosensors. Meanwhile quite a number of different strategies have emerged to fulfill this task which are summarized here. We ourselves have especially concentrated on the 'Product Enrichment Strategy', where the enrichment of products of a given analyte by a suitable biochemical reaction within the narrow confinement of etched ion tracks is used to amplify the product's signal for high-sensitivity biosensing. We also report on the application of nuclear analysis techniques for obtaining a deeper insight into these sensor structures, for the sake of their further optimization. Last not least we also discuss competing nanopore-based biosensing approaches.
Permanent Link: http://hdl.handle.net/11104/0260424