Water soluble poly(styrene sulfonate)-b-poly(vinylidene fluoride)-b-poly(styrene sulfonate) triblock copolymer nanoparticles

0460137 - ÚMCH 2017 RIV GB eng J - Journal Article
Černoch, Peter - Černochová, Zulfiya - Petrova, Svetlana - Kaňková, Dana - Kim, J.-S. - Vasu, V. - Asandei, A. D.
Water soluble poly(styrene sulfonate)-b-poly(vinylidene fluoride)-b-poly(styrene sulfonate) triblock copolymer nanoparticles.
RSC Advances. Roč. 6, č. 60 (2016), s. 55374-55381. E-ISSN 2046-2069
R&D Projects: GA MŠMT(CZ) LH14038
Institutional support: RVO:61389013
Keywords : polystyrenesulfonate * poly(neopentyl styrenesulfonate) * PVDF
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 3.108, year: 2016

A visible light, Mn-2(CO)(2)-photomediated process was used to enable the iodine degenerative transfer controlled radical polymerization of vinylidene fluoride (VDF) initiated from I-(CF2)(6)-I, and the successive quantitative activation of the similar to CH2-CF2-I and similar to CF2-CH2-I chain ends of I-PVDF-I, to produce a series of PNpSS-b-PVDF-b-PNpSS triblock copolymers (NpSS/VDF/NpSS = 4/60/4, 15/60/15, 34/60/34) with neopentyl styrene sulfonate (NpSS), which upon NaN3 deprotection, afforded the corresponding PNaSS-b-PVDF-b-PNaSS. All blocks, as well as PVDF, PNpSS and PNaSS formed water stable dispersion/solutions following either nanoprecipitation from acetone (PVDF, PNpSS, and PNpSS-b-PVDF-b-PNpSS) or direct dissolution in water (PNaSS, PNaSS-b-PVDF-b-PNaSS). Remarkably, all PNaSS-b-PVDF-b-PNaSS triblocks also provided indefinitely stable systems even under the high ionic strength conditions of phosphate buffered saline (PBS) solutions, corresponding to cell-isotonic, pH = 7.4 conditions. These trends were found to be consistent with the block composition dependence of the apparent hydrodynamic radius (R-h), conductivity, and zeta potential (zeta), where R-h increases upon deprotection from about 35-25 nm to about 168-136 nm in water, and decreases to 133-86 nm in PBS solutions, zeta decreases from similar to-40 mV to similar to-70 mV in water and increases to similar to-18 mV in PBS, and where the conductivity is negligible for PNpSS-b-PVDF-b-PNpSS but then increases linearly to similar to 0.2 mS cm(-1) for PNaSS-b-PVDF-b-PNaSS in water to reach similar to 17 mS cm(-1) in PBS. Finally, the blocks were evaluated as promising F-19-MRI contrast agents.
Permanent Link: http://hdl.handle.net/11104/0260274