Degradation of Verapamil hydrochloride in water by gliding arc discharge

0459875 - ÚFP 2017 RIV GB eng J - Journal Article
Krishna, S. - Mašláni, Alan - Izdebski, T. - Horáková, M. - Klementová, Š. - Špatenka, P.
Degradation of Verapamil hydrochloride in water by gliding arc discharge.
Chemosphere. Roč. 152, June (2016), s. 47-54. ISSN 0045-6535. E-ISSN 1879-1298
Institutional support: RVO:61389021
Keywords : Gliding arc discharge * Emission spectroscopy * Pharmaceuticals * Half-life * Degradation mechanism
Subject RIV: BL - Plasma and Gas Discharge Physics
Impact factor: 4.208, year: 2016
http://www.sciencedirect.com/science/article/pii/S0045653516302442

This study investigated the influence of gliding arc plasma discharge on the degradation of Verapamil hydrochloride in water. The plasma discharge was characterized by means of optical emission spectroscopy. Spectra of various atomic and molecular species were observed. Aqueous solution of Verapamil hydrochloride was exposed to gliding arc discharge operated in continuous discharge at atmospheric pressure and room temperature. The identification of Verapamil, the degradation mechanisms of Verapamil and its transformation products were performed using liquid chromatography - mass spectrometry (HPLC-MS). Experimental results indicate that the atmospheric pressure gliding arc plasma treatment has noticeable effects on Verapamil with satisfactory degradation efficiency. Plausible mechanisms of the degradation were discussed
Permanent Link: http://hdl.handle.net/11104/0260037