Carbon Nanomaterials for Biomedical Applications

0459780 - ÚOCHB 2017 RIV CH eng M - Monography Chapter
Řehoř, Ivan - Šlegerová, Jitka - Havlík, Jan - Raabová, Helena - Hývl, Jakub - Muchová, Eva - Cígler, Petr
Nanodiamonds: Behavior in Biological Systems and Emerging Bioapplications.
Carbon Nanomaterials for Biomedical Applications. Cham: Springer, 2016 - (Zhang, M.; Naik, R.; Dai, L.), s. 319-361. Springer Series in Biomaterials Science and Engineering, 5. ISBN 978-3-319-22860-0
R&D Projects: GA MZd(CZ) NV15-33094A
Institutional support: RVO:61388963
Keywords : functionalized diamond nanoparticles * surface functionalization * core-shell designs
Subject RIV: CC - Organic Chemistry

In the past decade, nanodiamonds (NDs) have been recognized as a promising nanomaterial for bioapplications such as bioimaging and drug delivery in nanoscale medicine. Here, we present a comprehensive survey of current research on ND interactions with biological systems, including their biocompatibility, cellular internalization, localization, and targeting by surface-attached ligands. We critically assess the differences between different types of NDs, such as detonation NDs and high-pressure high-temperature (HPHT) NDs. We describe NDs' physicochemical properties, structure, and available synthetic modifications by small molecules and biomolecules. Finally, we discuss emerging medical applications and bioapplications of these low-toxicity carbon nanoparticles.

Permanent Link: http://hdl.handle.net/11104/0259942