The impact of silica encapsulated cobalt zinc ferrite nanoparticles on DNA, lipids and proteins of rat bone marrow mesenchymal stem cells.

0459627 - ÚEM 2017 RIV GB eng J - Journal Article
Novotná, Božena - Turnovcová, Karolína - Veverka, Pavel - Rössner ml., Pavel - Bagryantseva, Yana - Herynek, Vít - Zvatora, P. - Vosmanská, M. - Klementová, M. - Syková, Eva - Jendelová, Pavla
The impact of silica encapsulated cobalt zinc ferrite nanoparticles on DNA, lipids and proteins of rat bone marrow mesenchymal stem cells.
Nanotoxicology. Roč. 10, č. 6 (2016), s. 662-670. ISSN 1743-5390. E-ISSN 1743-5404
R&D Projects: GA ČR(CZ) GAP304/12/1370; GA MŠMT(CZ) LO1309; GA MŠMT(CZ) LO1508
Institutional support: RVO:68378041 ; RVO:68378271
Keywords : comet assay * cytotoxicity * genotoxicity * lipid peroxidation
OECD category: Cell biology
Impact factor: 6.428, year: 2016
Method of publishing: Limited access
https://www.tandfonline.com/doi/full/10.3109/17435390.2015.1107144

Cobalt zinc ferrite nanoparticles (Co0.5Zn0.5Fe2O4+γ [CZF-NPs]) encapsulated by amorphous silica we prepared and tested in order to find a safe contrast agent and magnetic label for tracking transplanted cells within an organism using magnetic resonance imaging (MRI). No harmful effects were detected in cells exposed to the low dose of CZF-NPs. Nevertheless, the labeled cells still exhibited an adequate relaxation rate for MRI in repeated experiments and ICP-MS confirmed sufficient magnetic label concentrations inside the cells.
Permanent Link: http://hdl.handle.net/11104/0259808