Molecular-level control of ciclopirox olamine release from poly(ethylene oxide)-based mucoadhesive buccal films: exploration of structure–property relationships with solid-state NMR

0459119 - ÚMCH 2017 RIV US eng J - Journal Article
Urbanová, Martina - Gajdosova, M. - Steinhart, Miloš - Vetchy, D. - Brus, Jiří
Molecular-level control of ciclopirox olamine release from poly(ethylene oxide)-based mucoadhesive buccal films: exploration of structure–property relationships with solid-state NMR.
Molecular Pharmaceutics. Roč. 13, č. 5 (2016), s. 1551-1563. ISSN 1543-8384. E-ISSN 1543-8392
R&D Projects: GA ČR(CZ) GA14-03636S; GA MŠMT(CZ) LO1507
Institutional support: RVO:61389013
Keywords : mucoadhesive buccal films * ciclopirox olamine * PEO
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 4.440, year: 2016

Mucoadhesive buccal films (MBFs) provide an innovative way to facilitate the efficient site-specific delivery of active compounds while simultaneously separating the lesions from the environment of the oral cavity. The structural diversity of these complex multicomponent and mostly multiphase systems as well as an experimental strategy for their structural characterization at molecular scale with atomic resolution were demonstrated using MBFs of ciclopirox olamine (CPX) in a poly(ethylene oxide) (PEO) matrix as a case study. A detailed description of each component of the CPX/PEO films was followed by an analysis of the relationships between each component and the physicochemical properties of the MBFs.
Permanent Link: http://hdl.handle.net/11104/0259381