Nanobiomaterials in Hard Tissue Engineering

0458563 - FGÚ 2017 RIV NL eng M - Monography Chapter
Bačáková, Lucie - Filová, Elena - Lišková, Jana - Kopová, Ivana - Vandrovcová, Marta - Havlíková, Jana
Nanostructured materials as substrates for the adhesion, growth, and osteogenic differentiation of bone cells.
Nanobiomaterials in Hard Tissue Engineering. Amsterdam: Elsevier, 2016 - (Grumezescu, A.), s. 103-153. Applications of Nanobiomaterials, 4. ISBN 978-0-323-42862-0
R&D Projects: GA ČR(CZ) GBP108/12/G108
Institutional support: RVO:67985823
Keywords : bone tissue engineering * nanoroughness * osteoblast * alloys * carbon coating * ceramics * porous scaffold * nanofibers * nanoparticles
Subject RIV: EI - Biotechnology ; Bionics

Nanostructured materials, particularly those with hierarchically organized macro-, micro-, and nanostructure, imitating the architecture of the natural bone tissue, are promising materials for construction of bone implants and bone tissue engineering. The nanoscale surface roughness has been unambiguously considered as a factor positively influencing the adhesion, growth, and phenotypic maturation of cells. The explanation is that the nanosized irregularities on a material surface mimic the nanoscale architecture of the native ECM. Materials already used or developed for bone implantation and bone tissue engineering can be divided into two basic groups: materials interacting with cells only on their surface, referred as two-dimensional (2D) materials, and materials enabling the ingrowth of cell into their inner structure, referred as three-dimensional (3D) materials. On 2D surfaces, the nanoscale features can be achieved by two main types of modification: subtractive and additive. Both technologies have been often combined. In 3D materials, nanostructure can be achieved by, for example, reinforcing macro- or microporous and micro- or nanofibrous polymeric scaffolds with ceramic, carbon-based, metal-based, or other nanoparticles. In this chapter, we summarize our experience and the experience of other authors concerning the adhesion, growth, and differentiation of osteogenic cells on 2D and 3D materials containing nanoscale features created by various technologies.
Permanent Link: http://hdl.handle.net/11104/0258822