Muscarinic Receptor: From Structure to Animal Models

0458560 - FGÚ 2017 RIV US eng M - Monography Chapter
El-Fakahany, E. E. - Jakubík, Jan
Radioligand Binding at Muscarinic Receptors.
Muscarinic Receptor: From Structure to Animal Models. New York: Springer, 2016 - (Mysliveček, J.; Jakubík, J.), s. 37-68. Neuromethods, 107. ISBN 978-1-4939-2857-6
R&D Projects: GA ČR(CZ) GBP304/12/G069
Institutional support: RVO:67985823
Keywords : muscarinic acetylcholine receptors * radioligand binding
Subject RIV: ED - Physiology

Five subtypes of muscarinic acetylcholine receptors denoted M1 through M5 have been cloned. Muscarinic receptors mediate a wide array of physiological functions and impairment of muscarinic signaling is involved in numerous pathological conditions including Alzheimer’s disease and schizophrenia. Reliable radioligand binding techniques allow study of involvement of individual muscarinic receptor subtypes in the physiology and pathology of muscarinic signaling, and study of the structure of muscarinic receptors and structure-activation relationship of muscarinic ligands. Here we discuss the current state of knowledge of radioligand binding experiments at muscarinic receptors from the perspective of available radioligands and selective unlabeled muscarinic ligands.
Permanent Link: http://hdl.handle.net/11104/0258819