Microglial Janus kinase/signal transduction and activator of transcription 3 pathway activity directly impacts astrocyte and spinal neuron characteristics

0458427 - FGÚ 2017 RIV US eng J - Journal Article
Molet, J. - Mauborgne, A. - Diallo, Michael - Armand, V. - Geny, D. - Villanueva, L. - Boucher, Y. - Pohl, M.
Microglial Janus kinase/signal transduction and activator of transcription 3 pathway activity directly impacts astrocyte and spinal neuron characteristics.
Journal of Neurochemistry. Roč. 136, č. 1 (2016), s. 133-147. ISSN 0022-3042. E-ISSN 1471-4159
R&D Projects: GA MŠMT(CZ) EE2.3.30.0025
Institutional support: RVO:67985823
Keywords : astrocytes * cell plasticity * JAK/STAT3 pathway * microglia conditioned media * spinal cord neurons
Subject RIV: FH - Neurology
Impact factor: 4.083, year: 2016

We show that the activity of JAK/STAT3 pathway in microglial cells confers them a specific signaling modality toward neighboring cells, promoting astrocyte proliferation and changes in neuronal morphology. These in vitro data suggest that the early JAK/STAT3 activation in spinal cord microglia, associated with peripheral nerve injury, participates in functional alteration of various cell populations and in spinal tissue remodeling.
Permanent Link: http://hdl.handle.net/11104/0258696