Singlet Oxygen : Applications in Biosciences and Nanosciences

0458287 - ÚACH 2017 RIV GB eng M - Monography Chapter
Lang, Kamil - Mosinger, Jiří - Kubát, Pavel
Nanofibers and Nanocomposite Films for Singlet Oxygen-Based Applications.
Singlet Oxygen : Applications in Biosciences and Nanosciences. Vol. 1. Cambridge: Royal Society of Chemistry, 2016 - (Nonell, S.; Flors, C.), s. 305-321. Comprehensive Series in Photochemical & Photobiological Sciences, 13. ISBN 978-1-78262-038-9
R&D Projects: GA ČR(CZ) GA13-12496S
Institutional support: RVO:61388980 ; RVO:61388955
Keywords : Layered double hydroxides * immobilized meso-tetraphenylporphyrin * Photodynamic therapy
OECD category: Inorganic and nuclear chemistry; Physical chemistry (UFCH-W)

The development of photoactive nanomaterials producing singlet oxygen, 1O2, has blossomed as a field of great interest because of the ease with which their functionality is switched on and off by light, with a quick response, and their ability to do so without introducing other reactants into the system. In this chapter, we address the developing area of polymer nanofibers and nanocomposite films containing photosensitizers (PS) that are encapsulated or attached to the surface, with an emphasis on their photophysical properties, their ability to produce 1O2, and their potential use in constructing multifunctional platforms with photoantibacterial, photoantiviral, and photo-oxidative properties. Polymer nanofibers have several advantages over bulk polymers including their large specific surface area and high porosity, light weight, low cost, mechanical flexibility, light-transparency, and small diameters, which range from tens to hundreds of nanometers. The selection of polymers with high oxygen permeability and surface hydrophilicity (wettability) is crucial for achieving the efficient photo-oxidation effect of 1O2. Important experimental data that illuminate the correlation of these two parameters and performance are discussed, and examples from our laboratory and others are summarized. Potential directions for further developments are also highlighted.
Permanent Link: http://hdl.handle.net/11104/0258574