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Evaluation of respiration of mitochondria in cancer cells exposed to mitochondria-targeted agents.
- 1.0457446 - BTÚ 2016 RIV US eng J - Journal Article
Klučková, Katarína - Dong, L. F. - Bajziková, Martina - Rohlena, Jakub - Neužil, Jiří
Evaluation of respiration of mitochondria in cancer cells exposed to mitochondria-targeted agents.
Methods in molecular biology. Roč. 1265, 07 Oct 2015 (2015), s. 181-194. ISSN 1940-6029
R&D Projects: GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:86652036
Keywords : Animals * Antineoplastic Agents * drug effects * *pharmacology
Subject RIV: EB - Genetics ; Molecular Biology
Respiration is one of the major functions of mitochondria, whereby these vital organelles use oxygen to produce energy. Many agents that may be of potential clinical relevance act by targeting mitochondria, where they may suppress mitochondrial respiration. It is therefore important to evaluate this process and understand how this is modulated by small molecules. Here, we describe the general methodology to assess respiration in cultured cells, followed by the evaluation of the effect of one anticancer agent targeted to mitochondria on this process, and also how to assess this in tumor tissue.
Permanent Link: http://hdl.handle.net/11104/0257845
Number of the records: 1