Searching for Electrochemical Reduction Mechanism of Azidophenyl DNA Labels

0456528 - ÚOCHB 2016 RIV CZ eng C - Conference Paper (international conference)
Daňhel, Aleš - Trošanová, Zuzana - Balintová, Jana - Hocek, Michal - Fojta, Miroslav
Searching for Electrochemical Reduction Mechanism of Azidophenyl DNA Labels.
Sborník přednášek mezinárodní odborné konference XXXIV. Moderní Elektrochemické Metody. Ústí nad Labem: Best Servis, 2014 - (Navrátil, T.; Fojta, M.; Pecková, K.), s. 31-35. ISBN 978-80-905221-2-1.
[Moderní Elektrochemické Metody /34./. Jetřichovice (CZ), 19.05.2014-23.05.2014]
R&D Projects: GA ČR GBP206/12/G151; GA MŠMT EE2.3.30.0019
Institutional support: RVO:68081707 ; RVO:61388963
Keywords : aromatic azides * DNA labels * mercury electrode * reduction mechanism * voltammetry
Subject RIV: CG - Electrochemistry

This contribution brings new information to sporadic scientific results concerned to electrochemical reduction of aromatic azides. Selected compounds used as perspective DNA labels or their structural constituents such as, 4-azidophenyltrifluoroboronic acid, 4-azidophenyl modified deoxycytidine and next probable analogous compounds and/or products of their reduction, were voltammetrically studied and compared to each other in order to reveal a mechanism of their electrochemical reduction at mercury electrodes in aqueous media. Preliminary results obtained by cyclic voltammetry at mercury and carbon based electrodes and by mass spectrometry of the products isolated from batch electrolysis on mercury pool by preparative chromatography are discussed.
Permanent Link: http://hdl.handle.net/11104/0257031