Design and synthesis of a novel trinuclear palladium(II) complex containing an oxime chelate ligand: determining the interaction mechanism with the DNA groove and BSA site I by spectroscopic and molecular dynamics simulation approaches

0456346 - FZÚ 2016 RIV GB eng J - Journal Article
Karami, K. - Lighvan, Z. M. - Barzani, S.A. - Faal, A.Y. - Poshteh-Shirani, M. - Khayamian, T. - Eigner, Václav - Dušek, Michal
Design and synthesis of a novel trinuclear palladium(II) complex containing an oxime chelate ligand: determining the interaction mechanism with the DNA groove and BSA site I by spectroscopic and molecular dynamics simulation approaches.
New Journal of Chemistry. Roč. 39, č. 11 (2015), s. 8708-8719. ISSN 1144-0546. E-ISSN 1369-9261
R&D Projects: GA ČR(CZ) GA14-03276S
Institutional support: RVO:68378271
Keywords : single-crystal structure analysis * paladium complex * trinuclear complex
Subject RIV: CC - Organic Chemistry
Impact factor: 3.277, year: 2015

The novel trinuclear Pd(II) complex with an aryl oxime ligand, [Pd3(C,N-(C6H4C(Cl)QNO)-4)6], was synthesized and structurally characterized by elemental analysis (C, H, N), IR, resonance signals in the NMR, and single crystal X-ray crystallography. The interaction ability of the complex with native calf thymus DNA (CT-DNA) was monitored as a function of the metal complex–DNA molar ratio by UV-Vis absorption spectrophotometry, fluorescence spectroscopy, circular dichroism (CD) and thermal denaturation methods. All the experimental evidence indicated that this complex could strongly bind to CT-DN A via a groove mechanism. Further, the albumin interactions of the complex were investigated using fluorescence quenching and synchronous fluorescence spectra. The results of fluorescence titration suggested that the fluorescence quenching of BSA by the complex was a static quenching procedure.
Permanent Link: http://hdl.handle.net/11104/0256878