Nitro-oleic acid modulates classical and regulatory activation of macrophages and their involvement in pro-fibrotic responses

0456291 - BFÚ 2016 RIV US eng J - Journal Article
Ambrožová, Gabriela - Martíšková, Hana - Koudelka, A. - Ravekes, T. - Rudolph, T.K. - Klinke, A. - Rudolph, V. - Freeman, B.A. - Woodcock, S.R. - Kubala, Lukáš - Pekarová, Michaela
Nitro-oleic acid modulates classical and regulatory activation of macrophages and their involvement in pro-fibrotic responses.
Free Radical Biology and Medicine. Roč. 90, JAN 2016 (2016), s. 252-260. ISSN 0891-5849. E-ISSN 1873-4596
R&D Projects: GA ČR(CZ) GP13-40824P
Grant - others:GAAV(CZ) M200041208
Institutional support: RVO:68081707
Keywords : Nitro-fatty acids * Nitro-oleic acid * Macrophages
Subject RIV: BO - Biophysics
Impact factor: 5.606, year: 2016

Inflammation is an immune response triggered by microbial invasion and/or tissue injury. While acute inflammation is directed toward invading pathogens and injured cells, thus enabling tissue regeneration, chronic inflammation can lead to severe pathologies and tissue dysfunction. These processes are linked with macrophage polarization into specific inflammatory "M1-like" or regulatory "M2-like" subsets. Nitro-fatty acids (NO2-FAs), produced endogenously as byproducts of metabolism and oxidative inflammatory conditions, may be useful for treating diseases associated with dysregulated immune homeostasis. The goal of this study was to characterize the role of nitro-oleic acid (OA-NO2) in regulating the functional specialization of macrophages induced by bacterial lipopolysaccharide or interleukin-4, and to reveal specific signaling mechanisms which can account for OA-NO2-dependent modulation of inflammation and fibrotic responses.
Permanent Link: http://hdl.handle.net/11104/0256850