Capillary isotachophoresis with ESI-MS detection: Methodology for highly sensitive analysis of ibuprofen and diclofenac in waters

0456038 - ÚIACH 2016 RIV NL eng J - Journal Article
Malá, Zdeňka - Gebauer, Petr - Boček, Petr
Capillary isotachophoresis with ESI-MS detection: Methodology for highly sensitive analysis of ibuprofen and diclofenac in waters.
Analytica Chimica Acta. Roč. 907, FEB (2016), s. 1-6. ISSN 0003-2670. E-ISSN 1873-4324
R&D Projects: GA ČR(CZ) GA13-05762S
Institutional support: RVO:68081715
Keywords : isotachophoresis * mass spectrometric detection * Diclofenac * Ibuprofen
Subject RIV: CB - Analytical Chemistry, Separation
Impact factor: 4.950, year: 2016

The possibilities of reaching higher sensitivity in capillary electrophoretic analyses of complex samples with ESI-MS detection were investigated on the example of analysis of diclofenac and ibuprofen in waters. The applied separation approach is based on application of isotachophoresis that ensures permanent stacking of analytes until they reach the detector. Investigation of the possibilities of MS detector optimization have shown that optimization of fragmentor voltage and working in the SIM mode with collection of data for multiple fragments both increases the method specificity and approx. doubles its sensitivity.
Permanent Link: http://hdl.handle.net/11104/0256621