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Age-related changes in the lateral lipid distribution in a human lens described by mass spectrometry imaging
- 1.0456001 - MBÚ 2016 RIV GB eng J - Journal Article
Pól, Jaroslav - Faltýsková, Helena - Krásný, Lukáš - Volný, Michael - Vláčil, O. - Hajdúch, M. - Lemr, Karel - Havlíček, Vladimír
Age-related changes in the lateral lipid distribution in a human lens described by mass spectrometry imaging.
European Journal of Mass Spectrometry. Roč. 21, č. 3 (2015), s. 297-303. ISSN 1469-0667
R&D Projects: GA MŠMT(CZ) LD13038; GA MŠMT LO1509
Grant - others:OPPC(XE) CZ.2.16/3.1.00/24023
Institutional support: RVO:61388971
Keywords : lens * eye * imaging
Subject RIV: CB - Analytical Chemistry, Separation
Impact factor: 1.011, year: 2015
The lateral lipid distribution in eye lenses of three human donors were studied by matrix-assisted laser desorption ionization imaging mass spectrometry using a high mass resolution. By using exact mass measurements this study shows the relationship between the aging process and the number of lipids detected as well as between aging and the abundance of products derived from sphingomyelins by hydrolysis. Variable lipid composition was also observed in the nuclear, barrier, or cortex regions of the lens samples. This is the first study that suggests the distribution of lysolipids as a potential biomarker panel for the aging of human lens tissue.
Permanent Link: http://hdl.handle.net/11104/0256582
Number of the records: 1