Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice

0455741 - ÚMG 2016 RIV AU eng J - Journal Article
Kazerounian, S. - Ciarlini, P.D.S.C. - Yuan, D. - Ghazvinian, R. - Alberich-Jorda, Meritxell - Joshi, M. - Zhang, H. - Beggs, A.H. - Gazda, H.T.
Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice.
Journal of Cancer. Roč. 7, č. 1 (2016), s. 32-36. ISSN 1837-9664. E-ISSN 1837-9664
R&D Projects: GA MŠMT LK21307
Institutional support: RVO:68378050
Keywords : Ribosomal proteins RPL5 and RPS24 * Diamond-Blackfan anemia * Soft tissue sarcoma
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.916, year: 2016

Diamond-Blackfan anemia (DBA) is an inherited bone marrow failure syndrome associated with ribosomal protein (RP) gene mutations. Recent studies have also demonstrated an increased risk of cancer predisposition among DBA patients. In this study, we report the formation of soft tissue sarcoma in the Rpl5 and Rps24 heterozygous mice. Our observation suggests that even though one wild-type allele of the Rpl5 or Rps24 gene prevents anemia in these mice, it still predisposes them to cancer development.
Permanent Link: http://hdl.handle.net/11104/0256358