Number of the records: 1  

Cyclam Derivatives with a Bis(phosphinate) or a Phosphinato-Phosphonate Pendant Arm: Ligands for Fast and Efficient Copper(II) Complexation for Nuclear Medical Applications

  1. 1.
    0455366 - ÚOCHB 2016 RIV US eng J - Journal Article
    David, T. - Kubíček, V. - Gutten, Ondrej - Lubal, P. - Kotek, J. - Pietzsch, H.-J. - Rulíšek, Lubomír - Hermann, P.
    Cyclam Derivatives with a Bis(phosphinate) or a Phosphinato-Phosphonate Pendant Arm: Ligands for Fast and Efficient Copper(II) Complexation for Nuclear Medical Applications.
    Inorganic Chemistry. Roč. 54, č. 24 (2015), s. 11751-11766. ISSN 0020-1669. E-ISSN 1520-510X
    R&D Projects: GA ČR(CZ) GA14-31419S
    Grant - others:COST(XE) TD1004
    Institutional support: RVO:61388963
    Keywords : cyclam derivatives * radiolabelling * quantum chemical calculations * copper(II) chelation
    Subject RIV: CA - Inorganic Chemistry
    Impact factor: 4.820, year: 2015

    Cyclam derivatives bearing one geminal bis(phosphinic acid), -CH2PO2HCH2PO2H2 (H2L1), or phosphinic-phosphonic acid, -CH2PO2HCH2PO3H2 (H3L2), pendant arm were synthesized and studied as potential copper(II) chelators for nuclear medical applications. The ligands showed good selectivity for copper(II) over zinc(II) and nickel(II) ions (log K-CuL = 25.8 and 27.7 for H2L1 and H3L2, respectively). Kinetic study revealed an unusual threestep complex formation mechanism. Quantum-chemical calculations showed small energetic differences between the isomeric complexes of H3L2 compared with analogous data for isomeric complexes of cyclam derivatives with one or two methylphosphonic acid pendant arm(s). Acid-assisted dissociation proved the kinetic inertness of the complexes. Preliminary radiolabeling of H2L1 and H3L2 with Cu-64 was fast and efficient, even at room temperature, giving specific activities of around 70 GBq of Cu-64 per 1 mu mol of the ligand (pH 6.2, 10 min, ca. 90 equiv of the ligand). The rare combination of simple ligand synthesis, very fast copper(II) complex formation, high thermodynamic stability, kinetic inertness, efficient radiolabeling, and expected low bone tissue affinity makes such ligands suitably predisposed to serve as chelators of copper radioisotopes in nuclear medicine.
    Permanent Link: http://hdl.handle.net/11104/0255999

     
     
Number of the records: 1  

  This site uses cookies to make them easier to browse. Learn more about how we use cookies.