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Epigenetics and a new look on metabolic syndrome
- 1.0454386 - FGÚ 2016 RIV CZ eng J - Journal Article
Kuneš, Jaroslav - Vaněčková, Ivana - Mikulášková, Barbora - Behuliak, Michal - Maletínská, L. - Zicha, Josef
Epigenetics and a new look on metabolic syndrome.
Physiological Research. Roč. 64, č. 5 (2015), s. 611-620. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA MZd(CZ) NV15-25396A; GA ČR(CZ) GA15-08679S
Institutional support: RVO:67985823
Keywords : metabolic syndrome * epigenetics * transgenerational inheritance * gene-environmental interactions * obesity * hypertension
Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition
Impact factor: 1.643, year: 2015
The ability of environmental factors to promote phenotype changes by epigenetic DNA modifications (i.e. DNA methylation, histone modifications) was demonstrated to play an important role in the development and predisposition to particular symptoms of metabolic syndrome. There is no doubt that the early life, such as the fetal and perinatal periods, is critical for metabolic syndrome development and therefore critical for prevention of this disease. Moreover, these changes are visible not only in individuals exposed to environmental factors but also in the subsequent progeny for multiple generations and this phenomenon is called transgenerational inheritance
Permanent Link: http://hdl.handle.net/11104/0255075
Number of the records: 1