Modulation of cardiac connexin-43 by omega-3 fatty acid ethyl-ester supplementation demonstrated in spontaneously diabetic rats

0454188 - FGÚ 2016 RIV CZ eng J - Journal Article
Radošinská, J. - Kurahara, L. H. - Hiraishi, K. - Viczenczová, C. - Egan Beňová, T. - Szeiffová Bačová, B. - Dosenko, V. - Navarová, J. - Obšitník, B. - Imanaga, I. - Soukup, Tomáš - Tribulová, N.
Modulation of cardiac connexin-43 by omega-3 fatty acid ethyl-ester supplementation demonstrated in spontaneously diabetic rats.
Physiological Research. Roč. 64, č. 6 (2015), s. 795-806. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA MŠMT(CZ) 7AMB14SK123
Institutional support: RVO:67985823
Keywords : diabetes * omega-3 fatty acids * cardiac connexin-43 * PKC * ultrastructure
Subject RIV: ED - Physiology
Impact factor: 1.643, year: 2015

Omega-3 intake reduced blood glucose, triglycerides, and cholesterol in diabetic rats and this was associated with improved integrity of cardiomyocytes and capillaries in the heart. Myocardial Cx43 mRNA and protein levels were higher in diabetic versus non-diabetic rats and were further enhanced by omega-3. The ratio of phosphorylated (functional) to non-phosphorylated Cx43 was lower in diabetic compared to non-diabetic rats but was increased by omega-3, in part due to up-regulation of PKC-epsilon. Spontaneously diabetic rats at an early stage of disease benefit from omega-3 intake due to its hypoglycemic effect, upregulation of myocardial Cx43, and preservation of cardiovascular ultrastructure. These findings indicates that supplementation of omega-3 may be beneficial also in the management of diabetes in humans
Permanent Link: http://hdl.handle.net/11104/0254888