Information transfer through a signaling module with feedback: A perturbative approach

0454137 - FGÚ 2016 RIV IE eng J - Journal Article
Aquino, G. - Zápotocký, Martin
Information transfer through a signaling module with feedback: A perturbative approach.
Biosystems. Roč. 136, Oct (2015), s. 66-72. ISSN 0303-2647. E-ISSN 1872-8324
R&D Projects: GA ČR(CZ) GBP304/12/G069
Institutional support: RVO:67985823
Keywords : signal transduction * communication channel * poisson process * information theory * feedback loop * Non-Markovian process
Subject RIV: ED - Physiology
Impact factor: 1.495, year: 2015

Signal transduction in biological cells is effected by signaling pathways that typically include multiple feedback loops. Here we analyze information transfer through a prototypical signaling module with biochemical feedback. Using a novel perturbative approach, we compute the rate with which information about the input is gained from observation of the output. We obtain an explicit analytical result valid to first order in feedback strength and to second order in the strength of input
Permanent Link: http://hdl.handle.net/11104/0254835