Diffusion kurtosis imaging detects microstructural alterations in brain of α-synuclein overexpressing transgenic mouse model of Parkinson’s disease: a pilot study

0453900 - ÚPT 2016 US eng A - Abstract
Latta, P. - Khainar, A. - Dražanová, Eva - Kučerová, J. - Arab, A. - Hutter-Paier, B. - Havas, D. - Windisch, M. - Starčuk jr., Zenon - Tomanek, B. - Rektorová, I.
Diffusion kurtosis imaging detects microstructural alterations in brain of α-synuclein overexpressing transgenic mouse model of Parkinson’s disease: a pilot study.
Proceedings of the International Society for Magnetic Resonance in Medicine (ISMRM). Vol. 23. Berkeley: Society of Magnetic Resonance, 2015. s. 2198.
[ISMRM. Annual Meeting and Exhibition /23./. 30.05.2015-05.06.2015, Toronto]
R&D Projects: GA MŠMT(CZ) LO1212; GA MŠMT ED0017/01/01
Institutional support: RVO:68081731
Keywords : Parkinson’s disease * MRI * diffusion kurtosis imaging * diffusion tensor imaging
Subject RIV: FH - Neurology

The development of “neuroprotective” treatments is a central challenge for future Parkinson’s Disease (PD) therapy. To evaluate efficacy and to monitor disease-modifying effects, reliable surrogate markers for early PD diagnosis and progression are needed when patients might still be eligible for neuroprotective treatment. Diffusion kurtosis imaging (DKI) is an extension of conventional diffusion tensor imaging (DTI) and it incorporates non-Gaussian water diffusion behavior in neural tissues. DKI allows non-invasive in vivo assessment of tissue microstructure by mapping water proton motion within the tissue microenvironment. The aim of our study was to evaluate whether diffusion imaging as assessed by DKI metrics provides a sensitive tool for differentiating between transgenic mice over-expressing human α-synuclein (TNWT-61) and wild-type (WT) littermates.
Permanent Link: http://hdl.handle.net/11104/0254606