Development of the acoustic startle response in rats and its change after early acoustic trauma

0452413 - ÚEM 2016 RIV NL eng J - Journal Article
Rybalko, Natalia - Chumak, Tetyana - Bureš, Zbyněk - Popelář, Jiří - Šuta, Daniel - Syka, Josef
Development of the acoustic startle response in rats and its change after early acoustic trauma.
Behavioural Brain Research. Roč. 286, jul 1 (2015), s. 212-221. ISSN 0166-4328. E-ISSN 1872-7549
R&D Projects: GA ČR(CZ) GAP303/12/1347; GA ČR(CZ) GBP304/12/G069; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:68378041
Keywords : auditory system * rat * acoustic startle reflex * development * critical period * noise exposure
Subject RIV: FH - Neurology
Impact factor: 3.002, year: 2015

Compared to controls, noise exposure on P14 (125 dB SPL for 8, 12, or 25 min) produced transient hyper-reactivity to startle stimuli, manifested by a decrease of acoustic startle response (ASR) thresholds and an increase of ASR amplitudes. The hyper-reactivity of ASRs declined by P30; the ASR amplitudes in adult exposed rats were lower than in controls. The histological control did not reveal loss of hair cells in adult exposed rats, however, the number of inner hair cell ribbon synapses was significantly decreased, especially in the high-frequency part of the cochlea.
Permanent Link: http://hdl.handle.net/11104/0253464