Ultra-High-Frequency ECG Parameter as a New Marker for Prediction of Biventricular Pacemaker Responders

0452210 - ÚPT 2016 CZ eng A - Abstract
Reichlova, T. - Jurák, Pavel - Halámek, Josef - Plešinger, Filip - Lipoldová, J. - Novák, M. - Leinveber, P.
Ultra-High-Frequency ECG Parameter as a New Marker for Prediction of Biventricular Pacemaker Responders.
SMIT 2015. 27th International Conference of the Society for Medical Innovation and Technology. Abstract Book. Brno: Society for Medical Innovation and Technology, 2015. s. 63.
[SMIT 2015. International Conference of the Society for Medical Innovation and Technology/27./. 10.09.2015-12.09.2015, Brno]
Institutional support: RVO:68081731
Keywords : Ultra high frequency ECG * biventricular pacing * ventricular dyssynchrony * cardiac resynchronization therapy
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery

Biventricular implantable pacemaker (BiV) is usually recommended for heart failure patients with LVEF lower than 35% and QRS duration higher than 120ms. We introduce promising marker evaluating appropriateness and efficiency of Cardiac Resynchronization Therapy (CRT) recipients. We collected 12-lead UHF-ECG data of 24 CRT subjects – 5 minute resting measurement with sampling frequency 25 kHz, each before BiV and with BiV on (VV delay 0). A new parameter DYS was computed as time difference between two maxima of UHF envelopes computed from V1 and V6 leads in QRS complex in 500-1000Hz frequency band. DYS was calculated before and after implantation of BiV pacemaker. The two values of DYS were compared with standard QRS duration. The assumption for being responder for BiV is high value of DYS before CRT and significant DYS decrease during biventricular pacing – index of dyssynchrony decrease – DYSindex (ratio of DYS before and after). DYSindex higher than 1 identifies improvement in patient’s condition after BiV implantation. Subjects who do not benefit from Biv are in the lower part of the Table. These patients with DYSindex lower than 1 have simultaneously DYS parameter before stimulation ≤ 30ms. Thus the DYS parameter can serve as a new marker for responders prediction. This information cannot be derived from standard QRS duration values prior BiV implantation.
Permanent Link: http://hdl.handle.net/11104/0253244