Ontogenetic changes in contribution of calcium sensitization and calcium entry to blood pressure maintenance of Wistar–Kyoto and spontaneously hypertensive rats

0451952 - FGÚ 2016 RIV GB eng J - Journal Article
Behuliak, Michal - Vavřínová, Anna - Bencze, Michal - Polgárová, Kamila - Ergang, Peter - Kuneš, Jaroslav - Vaněčková, Ivana - Zicha, Josef
Ontogenetic changes in contribution of calcium sensitization and calcium entry to blood pressure maintenance of Wistar–Kyoto and spontaneously hypertensive rats.
Journal of Hypertension. Roč. 33, č. 12 (2015), s. 2443-2454. ISSN 0263-6352. E-ISSN 1473-5598
R&D Projects: GA ČR(CZ) GAP304/12/0259; GA ČR(CZ) GP14-16225P
Institutional support: RVO:67985823
Keywords : Ca2+ influx * Ca2+ sensitization * CPI-17 * fasudil * isolated arteries * nifedipine * Rho guanine nucleotide exchange factors * RhoA/Rho kinase
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
Impact factor: 5.062, year: 2015

Altered calcium sensitization (mediated by RhoA/Rho-kinase pathway) and enhanced calcium entry through L-type voltage-dependent calcium channels (L-VDCCs) participate in blood pressure (BP) maintenance of adult spontaneously hypertensive rats (SHRs). This study aimed to evaluate ontogenetic changes of these two pathways in BP control of SHR and Wistar-Kyoto (WKY) aged 3, 5, 7, 13, 26 and 42 weeks. The importance of RhoA/Rho-kinase pathway for BP/vascular tone control is attenuated in SHR from prehypertensive stages. Enhanced RhoA activation and/or CPI-17 phosphorylation might be counteracted by reduced expression of upstream activators of Rho-kinase (Rho-GEFs) together with lower expression of CPI-17 (in downstream cascade of Rho-kinase)
Permanent Link: http://hdl.handle.net/11104/0253005