Semi-automatic motion compensation of contrast-enhanced ultrasound images from abdominal organs for perfusion analysis

0450646 - ÚPT 2016 RIV GB eng J - Journal Article
Schafer, S. - Nylund, K. - Saevik, F. - Engjom, T. - Mézl, M. - Jiřík, Radovan - Dimcevski, G. - Gilja, O.H. - Tönnies, K.
Semi-automatic motion compensation of contrast-enhanced ultrasound images from abdominal organs for perfusion analysis.
Computers in Biology Medicine. Roč. 63, AUG 1 (2015), s. 229-237. ISSN 0010-4825. E-ISSN 1879-0534
R&D Projects: GA ČR GAP102/12/2380
Institutional support: RVO:68081731
Keywords : ultrasonography * motion analysis * motion compensation * registration * CEUS * contrast-enhanced ultrasound * perfusion * perfusion modeling
Subject RIV: FS - Medical Facilities ; Equipment
Impact factor: 1.521, year: 2015

This paper presents a system for correcting motion influences in time-dependent 2D contrast-enhanced ultrasound (CEUS) images to assess tissue perfusion characteristics. The system consists of a semiautomatic frame selection method to find images with out-of-plane motion as well as a method for automatic motion compensation. Translational and non-rigid motion compensation is applied by introducing a temporal continuity assumption. A study consisting of 40 clinical datasets was conducted to compare the perfusion with simulated perfusion using pharmacokinetic modeling. Overall, the proposed approach decreased the mean average difference between the measured perfusion and the pharmacokinetic model estimation. It was non-inferior for three out of four patient cohorts to a manual approach and reduced the analysis time by 41% compared to manual processing.
Permanent Link: http://hdl.handle.net/11104/0251950