Estimation of Input Function from Dynamic PET Brain Data Using Bayesian Blind Source Separation

0450509 - ÚTIA 2016 RIV RS eng J - Journal Article
Tichý, Ondřej - Šmídl, Václav
Estimation of Input Function from Dynamic PET Brain Data Using Bayesian Blind Source Separation.
Computer Science and Information Systems. Roč. 12, č. 4 (2015), s. 1273-1287. ISSN 1820-0214. E-ISSN 1820-0214
R&D Projects: GA ČR GA13-29225S
Institutional support: RVO:67985556
Keywords : blind source separation * Variational Bayes method * dynamic PET * input function * deconvolution
Subject RIV: BB - Applied Statistics, Operational Research
Impact factor: 0.623, year: 2015
http://library.utia.cas.cz/separaty/2015/AS/tichy-0450509.pdf

Selection of regions of interest in an image sequence is a typical prerequisite step for estimation of time-activity curves in dynamic positron emission tomography (PET). This procedure is done manually by a human operator and therefore suffers from subjective errors. Another such problem is to estimate the input function. It can be measured from arterial blood or it can be searched for a vascular structure on the images which is hard to be done, unreliable, and often impossible. In this study, we focus on blind source separation methods with no needs of manual interaction. Recently, we developed sparse blind source separation and deconvolution (S-BSS-vecDC) method for separation of original sources from dynamic medical data based on probability modeling and Variational Bayes approximation methodology. In this paper, we extend this method and we apply the methods on dynamic brain PET data and application and comparison of derived algorithms with those of similar assumptions are given. The S-BSS-vecDC algorithm is publicly available for download.
Permanent Link: http://hdl.handle.net/11104/0252672