Single high-concentration capsaicin application prevents c-Fos expression in spinothalamic and postsynaptic dorsal column neurons after surgical incision

0449363 - FGÚ 2016 RIV GB eng J - Journal Article
Uchytilová, Eva - Špicarová, Diana - Paleček, Jiří
Single high-concentration capsaicin application prevents c-Fos expression in spinothalamic and postsynaptic dorsal column neurons after surgical incision.
European Journal of Pain. Roč. 19, č. 10 (2015), s. 1496-1505. ISSN 1090-3801. E-ISSN 1532-2149
R&D Projects: GA ČR(CZ) GBP304/12/G069; GA MŠMT(CZ) LH12058; GA ČR(CZ) GPP303/12/P510; GA MŠMT(CZ) EE2.3.30.0025; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:67985823
Keywords : pain * spinothalamic * capsaicin * TRPV1 * PSDC
Subject RIV: FH - Neurology
Impact factor: 2.900, year: 2015

There was a robust increase in c-Fos immunopositivity in the STT and PSDC neurons, in the control animals after a plantar incision. This increase in c-Fos expression was significantly attenuated in animals in which a single high-concentration capsaicin injection was made intradermally at the incision site 24 h before the surgery. Our results suggest that activation of both STT and PSDC neurons is involved in development of pain states present after surgical incision and that TRPV1-containing peripheral nerve fibres are needed for c-Fos expression in these dorsal horn neurons after plantar incision
Permanent Link: http://hdl.handle.net/11104/0250952