Considerations on electrolysis in electromembrane extraction of basic drugs

0448871 - ÚIACH 2016 RIV CZ eng C - Conference Paper (international conference)
Šlampová, Andrea - Kubáň, Pavel - Boček, Petr
Considerations on electrolysis in electromembrane extraction of basic drugs.
CECE 2015. 12th International Interdisciplinary Meeting on Bioanalysis. Brno: Ústav analytické chemie AV ČR, v. v. i, 2015 - (Foret, F.; Křenková, J.; Drobníková, I.; Klepárník, K.), s. 198-201. ISBN 978-80-904959-3-7.
[CECE 2015. International Interdisciplinary Meeting on Bioanalysis /12./. Brno (CZ), 21.09.2015-23.09.2015]
R&D Projects: GA ČR(CZ) GA13-05762S
Institutional support: RVO:68081715
Keywords : electrolysis * electromembrane extraction * basic drugs
Subject RIV: CB - Analytical Chemistry, Separation
http://www.ce-ce.org/CECE2015/CECE%202015%20proceedings_full.pdf

Electrolysis may significantly affect composition and pH values of non-optimized acceptor solutions and have fatal consequences on quantitative EME results for weak and medium strong analytes. Acceptor solutions consisting of high concentrations of weak acids have therefore been proposed as suitable operational solutions for electromembrane extraction (EME) of selected basic drugs. 500 mM formic acid efficiently eliminated the electrolytically produced OH– ions, offered constant pH and thus long-term EME performance and was easily compatible with subsequent analytical methods. Maximum EME recoveries ranged from 66 to 89% and were constant between 40 and 80 min of EME and no back-extraction of the analytes into donor solutions was observed.
Permanent Link: http://hdl.handle.net/11104/0250466