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Changes in the Sterol Composition of the Plasma Membrane Affect Membrane Potential, Salt Tolerance and the Activity of Multidrug Resistance Pumps in Saccharomyces cerevisiae
- 1.0448361 - FGÚ 2016 RIV US eng J - Journal Article
Kodedová, Marie - Sychrová, Hana
Changes in the Sterol Composition of the Plasma Membrane Affect Membrane Potential, Salt Tolerance and the Activity of Multidrug Resistance Pumps in Saccharomyces cerevisiae.
PLoS ONE. Roč. 10, č. 9 (2015), e0139306. ISSN 1932-6203. E-ISSN 1932-6203
R&D Projects: GA MŠMT(CZ) EE2.3.30.0025; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:67985823
Keywords : Saccharomyces cerevisiae * ergosterol synthesis * multidrug resistance * membrane potential * diS-C3(3) assay
Subject RIV: EE - Microbiology, Virology
Impact factor: 3.057, year: 2015
We investigated the impact of the deletions of genes from the final steps in the biosynthesis of ergosterol (ERG6, ERG2, ERG3, ERG5, ERG4) on the physiological function of the Saccharomyces cerevisiae plasma membrane by a combination of biological tests and the diS-C3(3) fluorescence assay. Most of the erg mutants were more sensitive than the wild type to salt stress or cationic drugs, their susceptibilities were proportional to the hyperpolarization of their plasma membranes
Permanent Link: http://hdl.handle.net/11104/0250086
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