Sterically stabilized spongosomes for multidrug delivery of anticancer nanomedicines

0448089 - ÚMCH 2016 RIV GB eng J - Journal Article
Chen, Y. - Angelova, A. - Angelov, Borislav - Drechsler, M. - Garamus, V. M. - Willumeit-Römer, R. - Zou, A.
Sterically stabilized spongosomes for multidrug delivery of anticancer nanomedicines.
Journal of Materials Chemistry B. Roč. 3, č. 39 (2015), s. 7734-7744. ISSN 2050-750X. E-ISSN 2050-7518
R&D Projects: GA ČR(CZ) GC15-10527J
Institutional support: RVO:61389013
Keywords : SAXS * soft matter * nanoparticles
Subject RIV: CF - Physical ; Theoretical Chemistry
Impact factor: 4.872, year: 2015

Multidrug delivery devices are designed to take advantage of the synergistic effects of anticancer agents in combination therapies. Here we report novel liquid crystalline self-assembled nanocarriers enhancing the activity of the phytochemical anticancer agent baicalin (BAI) in combination with Brucea javanica oil (BJO), which ensures safe formulations for clinical applications. Small-angle X-ray scattering (SAXS) and cryogenic transmission electron microscopy (cryo-TEM) evidenced the multicompartment, sponge-type nano-organization of the blank and multidrug-loaded liquid crystalline carriers. Physico-chemical stability of the sponge nanoparticles was achieved through PEGylation of the lipid membranes, which make up the drug nanocarriers. The proposed green nanotechnology for nanocarrier preparation by supramolecular self-assembly provided a multidrug encapsulation efficiency as high as 75%. The apoptosis study with the human lung carcinoma cell line A549 demonstrated improved efficacy of the multidrug delivery nanocarriers in comparison to the single-drug reservoirs. The obtained results evidenced the synergistic anticancer apoptotic effects of the multidrug-loaded nanosponge carriers and suggested the opportunity for in vivo translation towards the treatment of lung, gastrointestinal, and ovarian cancers.
Permanent Link: http://hdl.handle.net/11104/0250794