Mitochondrial DNA in Tumor Initiation, Progression, and Metastasis: Role of Horizontal mtDNA Transfer

0447207 - BTÚ 2016 RIV US eng J - Journal Article
Berridge, M.V. - Dong, L.-F. - Neužil, Jiří
Mitochondrial DNA in Tumor Initiation, Progression, and Metastasis: Role of Horizontal mtDNA Transfer.
Cancer Research. Roč. 75, č. 16 (2015), s. 3203-3208. ISSN 0008-5472. E-ISSN 1538-7445
R&D Projects: GA MŠMT(CZ) ED1.1.00/02.0109; GA ČR GA15-02203S
Institutional support: RVO:86652036
Keywords : MESENCHYMAL STEM-CELLS * TUNNELING NANOTUBES * CANCER-CELLS
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 8.556, year: 2015

Mitochondrial DNA (mtDNA), encoding 13 out of more than 1,000 proteins of the mitochondrial proteome, is of paramount importance for the bioenergetic machinery of oxidative phosphorylation that is required for tumor initiation, propagation, and metastasis. In stark contrast to the widely held view that mitochondria and mtDNA are retained and propagated within somatic cells of higher organisms, recent in vitro and in vivo evidence demonstrates that mitochondria move between mammalian cells. This is particularly evident in cancer where defective mitochondrial respiration can be restored and tumor-forming ability regained by mitochondrial acquisition. This paradigm shift in cancer cell biology and mitochondrial genetics, concerning mitochondrial movement between cells to meet bioenergetic needs, not only adds another layer of plasticity to the armory of cancer cells to correct damaged mitochondria, but also points to potentially new therapeutic approaches. (C) 2015 AACR.
Permanent Link: http://hdl.handle.net/11104/0249131