Effect of salicylic acid on early life stages of common carp (Cyprinus carpio)

0447087 - ÚBO 2016 RIV NL eng J - Journal Article
Živná, D. - Sehonová, P. - Plhalová, L. - Maršálek, P. - Blahová, J. - Prokeš, Miroslav - Divišová, L. - Stancová, V. - Dobšíková, R. - Tichý, F. - Široká, Z. - Svobodová, Z.
Effect of salicylic acid on early life stages of common carp (Cyprinus carpio).
Environmental Toxicology and Pharmacology. Roč. 40, č. 1 (2015), s. 319-325. ISSN 1382-6689. E-ISSN 1872-7077
Institutional support: RVO:68081766
Keywords : Pharmaceutical residues * NSAIDs * Oxidative stress * Lipid peroxidation
Subject RIV: GJ - Animal Vermins ; Diseases, Veterinary Medicine
Impact factor: 2.187, year: 2015

Environmental concentrations of pharmaceutical residues are often low; nevertheless, they are designed to have biological effects at low doses. The aim of this study was to assess the effects of salicylic acid on the growth and development of common carp (Cyprinus carpio) early life stages with respect to antioxidant defence enzymes. An embryo-larval toxicity test lasting 34 days was performed according to OECD guidelines 210 (Fish, Early-life Stage Toxicity Test). The tested concentrations were 0.004, 0.04, 0.4, 4 and 20 mg/l of salicylic acid. Hatching, early ontogeny, and both morphometric and condition characteristics were significantly influenced by subchronic exposure to salicylic acid. Also, changes in antioxidant enzyme activity and an increase in lipid peroxidation were observed. The LOEC value was found to be 0.004 mg/l salicylic acid. The results of our study confirm the suggestion that subchronic exposure to salicylic acid at environmental concentrations can have significant effects on aquatic vertebrates.
Permanent Link: http://hdl.handle.net/11104/0249021