Rosuvastatin ameliorates inflammation, renal fat accumulation, and kidney injury in transgenic spontaneously hypertensive rats expressing human C-reactive protein

0446300 - FGÚ 2016 RIV CZ eng J - Journal Article
Šilhavý, Jan - Zídek, Václav - Landa, Vladimír - Šimáková, Miroslava - Mlejnek, Petr - Oliyarnyk, O. - Malínská, H. - Kazdová, L. - Mancini, M. - Pravenec, Michal
Rosuvastatin ameliorates inflammation, renal fat accumulation, and kidney injury in transgenic spontaneously hypertensive rats expressing human C-reactive protein.
Physiological Research. Roč. 64, č. 3 (2015), s. 295-301. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA MŠMT(CZ) LH11049; GA MŠMT(CZ) LL1204; GA MZd(CZ) NT14325; GA ČR(CZ) GB14-36804G
Institutional support: RVO:67985823
Keywords : rosuvastatin * kidney damage * CRP * transgenic * spontaneously hypertensive rat
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 1.643, year: 2015

Recently, we derived “humanized” spontaneously hypertensive rats (SHR-CRP) in which transgenic expression of human CRP induces inflammation, oxidative stress, several features of metabolic syndrome and target organ injury. In the current study, we tested the effects of rosuvastatin on kidney injury in SHR-CRP males versus untreated SHR-CRP and SHR controls. In SHR-CRP transgenic rats, treatment with rosuvastatin, compared to untreated transgenic rats and SHR controls, was associated with significantly reduced systemic inflammation which was accompanied with activation of antioxidative enzymes in the kidney and with amelioration of histopathological changes in the kidney. These findings provide evidence that, in the presence of high CRP levels, rosuvastatin exhibits significant anti-inflammatory, anti-oxidative, and renoprotective effects
Permanent Link: http://hdl.handle.net/11104/0248280