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Science of Synthesis
- 1.0445914 - MBÚ 2016 RIV DE eng M - Monography Chapter
Martínková, Ludmila - Veselá, Alicja Barbara
Hydrolysis of Nitriles to Carboxylic Acids.
Science of Synthesis. Stuttgart: Georg Thieme Verlag KG Stuttgart, 2015 - (Faber, K.; Fessner, W.; Turner, N.), s. 277-302. Biocatalysis in Organic Synthesis 1. ISBN 978-3-13-174131-8
R&D Projects: GA ČR(CZ) GAP504/11/0394
Institutional support: RVO:61388971
Keywords : nitrilase * nitrile hydratase * amidase
Subject RIV: CE - Biochemistry
The biocatalytic hydrolysis of nitriles to carboxylic acids is catalyzed by either a nitrilase or a bienzymatic cascade system comprised of a nitrile hydratase and an amidase. Using the same enzymes, amides can be obtained as side products (by nitrilases) or as intermediates (by nitrile hydratases). The tendency to form amides is characteristic of some nitrilases and depends also on the substrate structure, a bulky or an electrophilic group enhancing the turnover of nitrile into amide.
Permanent Link: http://hdl.handle.net/11104/0257912
Number of the records: 1