Rapid diagnosis of methanol poisoning by direct coupling of microextraction techniques to capillary zone electrophoresis

0444986 - ÚIACH 2016 RIV SK eng C - Conference Paper (international conference)
Pantůčková, Pavla - Kubáň, Pavel - Boček, Petr
Rapid diagnosis of methanol poisoning by direct coupling of microextraction techniques to capillary zone electrophoresis.
Analytical Methods and Human Health. Conference Proceedings. Bratislava: Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, 2015, s. 252-253. ISBN 978-80-971179-5-5.
[International Conference Analytical Methods and Human Health /20./. Patince (SK), 15.06.2015-18.06.2015]
R&D Projects: GA ČR(CZ) GA13-05762S
Grant - others:GA AV ČR(CZ) R200311404
Institutional support: RVO:68081715
Keywords : methanol poisoning * microextraction techniques * capillary electrophoresis
Subject RIV: CB - Analytical Chemistry, Separation

A massive methanol poisoning reported in 2012 in the Czech Republic pointed out the need for development of a robust analytical method suitable for rapid methanol poisoning diagnosis. Formate is the major metabolite in methanol poisoning and is primarily responsible for its toxicity. Formate can also serve as a reliable marker of methanol poisoning since formate concentrations in blood can rise to 10-30 mM in case of acute methanol poisoning, which are almost two orders of magnitude higher than the reference range (0-0.4 mM) reported for blood formate in healthy individuals [1,2]. Several approaches based on capillary zone electrophoresis (CZE) have been reported for formate determination in blood samples and for methanol poisoning diagnosis recently [3-6].
Permanent Link: http://hdl.handle.net/11104/0247419