Translational regulation shapes the molecular landscape of complex disease phenotypes

0444838 - FGÚ 2016 RIV GB eng J - Journal Article
Schafer, S. - Adami, E. - Heinig, M. - Rodrigues, K. E. C. - Kreuchwig, F. - Šilhavý, Jan - van Heesch, S. - Simaite, D. - Rajewsky, N. - Cuppen, E. - Pravenec, Michal - Vingron, M. - Cook, S. A. - Hubner, N.
Translational regulation shapes the molecular landscape of complex disease phenotypes.
Nature Communications. Roč. 6, May 2015 (2015), s. 7200. E-ISSN 2041-1723
R&D Projects: GA ČR(CZ) GB14-36804G; GA MŠMT(CZ) LL1204; GA MŠMT(CZ) 7E10067
Institutional support: RVO:67985823
Keywords : translational regulation * RNA sequencing * ribosome profiling * rat
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 11.329, year: 2015

We perform genome-wide RNA sequencing and ribosome profiling in heart and liver tissues to investigate strain-specific translational regulation in the spontaneously hypertensive rat (SHR). We observed hundreds of strain-specific differences in translation, almost doubling the number of differentially expressed genes. The integration of genetic, transcriptional and translational data sets revealed distinct signatures in 30 UTR variation, RNA-binding protein motifs and miRNA expression associated with translational regulation of gene expression. Capturing interindividual differences in the translated genome will lead to new insights into the genes and regulatory pathways underlying disease phenotypes
Permanent Link: http://hdl.handle.net/11104/0247301