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Involvement of PKC epsilon in Cardioprotection Induced by Adaptation to Chronic Continuous Hypoxia
- 1.0444821 - FGÚ 2016 RIV CZ eng J - Journal Article
Holzerová, K. - Hlaváčková, Markéta - Žurmanová, J. - Borchert, Gudrun H. - Neckář, Jan - Kolář, František - Novák, F. - Nováková, O.
Involvement of PKC epsilon in Cardioprotection Induced by Adaptation to Chronic Continuous Hypoxia.
Physiological Research. Roč. 64, č. 2 (2015), s. 191-201. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA ČR(CZ) GAP303/12/1162; GA ČR(CZ) GA13-10267S
Institutional support: RVO:67985823
Keywords : chronic hypoxia * cardioprotection * ventricular myocytes * protein kinase C * PKC epsilon inhibitory peptide KP-1633
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
Impact factor: 1.643, year: 2015
The aim of this study was to analyse the expression of PKC epsilon after the adaptation to chronic continuous hypoxia (CNH) and to clarify its role in increased cardiac ischemic tolerance with the use of PKC epsilon inhibitory peptide KP-1633. Adaptation to CNH increased myocardial PKC epsilon at protein and mRNA levels. The application of KP-1633 blunted the hypoxia-induced salutary effects on cell viability and LDH release, while control peptide KP-1723 had no effect. This study indicates that PKC epsilon is involved in the cardioprotective mechanism induced by CNH
Permanent Link: http://hdl.handle.net/11104/0247289
Number of the records: 1