Number of the records: 1
Injectable nanoparticle-loaded hydrogel system for local delivery of sodium alendronate
- 1.0444432 - FGÚ 2016 RIV GB eng J - Journal Article
Posadowska, U. - Pařízek, Martin - Filová, Elena - Wlodarczyk-Biegun, M. - Kamperman, M. - Bačáková, Lucie - Pamula, E.
Injectable nanoparticle-loaded hydrogel system for local delivery of sodium alendronate.
International Journal of Pharmaceutics. Roč. 485, 1-2 (2015), s. 31-40. ISSN 0378-5173. E-ISSN 1873-3476
R&D Projects: GA MZd(CZ) NT13297
Institutional support: RVO:67985823
Keywords : sodium alendronate * PLGA * nanoparticles
Subject RIV: EI - Biotechnology ; Bionics
Impact factor: 3.994, year: 2015
Our system based on Aln-loaded PLGA nanoparticles suspended in gellan gum hydrogel matrix: (i) was found to be injectable and restored its elastic structure after extrusion, (ii) assured local and uniform drug delivery, and (iii) inhibited osteoclasts differentiation without affecting osteoblasts functions. The results show the potential of our approach for the local treatment of osteoporosis and other bone tissue pathologies
Permanent Link: http://hdl.handle.net/11104/0246952
Number of the records: 1