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Stem cells regenerative properties on new rat spinal fusion model
- 1.0444382 - FGÚ 2016 RIV CZ eng J - Journal Article
Klíma, K. - Vaněček, Václav - Kohout, A. - Jiroušek, Ondřej - Foltán, R. - Štulík, J. - Machoň, V. - Pavlíková, G. - Jendelová, Pavla - Syková, Eva - Šedý, Jiří
Stem cells regenerative properties on new rat spinal fusion model.
Physiological Research. Roč. 64, č. 1 (2015), s. 119-128. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA MZd(CZ) NT13477; GA ČR(CZ) GAP304/10/0320
Institutional support: RVO:67985823 ; RVO:68378297 ; RVO:68378041
Keywords : mesenchymal stem cells * bone graft substitute * spinal fusion
Subject RIV: FH - Neurology
Impact factor: 1.643, year: 2015
The purpose of this study was to establish a simple model of spinal fusion based on a rat model including verification of the possible use of titanium microplates with hydroxyapatite scaffold combined with human bone marrow-derived mesenchymal stem cells (MSCs). The new model of interspinous fusion was safe, easy, inexpensive, with zero mortality. We did not detect any substantial pathological changes or tumor formation after graft implantation. In the group with MSCs we described minor inflamatory response which indicates the imunomodulational and antiinflamatory role of MSCs
Permanent Link: http://hdl.handle.net/11104/0246919
Number of the records: 1