The effect of dynasore, a blocker of dynamin-dependent endocytosis, on spontaneous quantal and non-quantal release of acetylcholine in murine neuromuscular junctions

0444255 - FGÚ 2016 RIV RU eng J - Journal Article
Malomouzh, A. I. - Mukhitov, A. R. - Proskurina, S. E. - Vyskočil, František - Nikolsky, E. E.
The effect of dynasore, a blocker of dynamin-dependent endocytosis, on spontaneous quantal and non-quantal release of acetylcholine in murine neuromuscular junctions.
Doklady Biological Sciences. Roč. 459, č. 1 (2014), s. 330-333. ISSN 0012-4966
Institutional support: RVO:67985823
Keywords : non-guantal release * neuromuscular junction
Subject RIV: ED - Physiology

The hypothesis was tested that increase in spontaneous quantal secretion of ACh at neuromuscular synapse is accompanied by inhibition of the non-quantal release of the ACh because the rate of the vesicular endocytosis might be also increased. This ultimately restrains the number of ACh transporters integrated into the presynaptic membrane. After application of an inhibitor of endocytosis, dynasore, the non-quantal ACh release was not potentiated and the role of endocytosis in this process remains uncertain
Permanent Link: http://hdl.handle.net/11104/0246965