Preserved cardiac mitochondrial function and reduced ischaemia/reperfusion injury afforded by chronic continuous hypoxia: Role of opioid receptors

0444243 - FGÚ 2016 RIV AU eng J - Journal Article
Maslov, L. N. - Naryzhnaya, N. V. - Prokudina, E. S. - Kolář, František - Gorbunov, A. S. - Zhang, Y. - Wang, H. - Tsibulnikov, S.Yu. - Portnichenko, A. G. - Lasukova, T. V. - Lishmanov, Yu. B.
Preserved cardiac mitochondrial function and reduced ischaemia/reperfusion injury afforded by chronic continuous hypoxia: Role of opioid receptors.
Clinical and Experimental Pharmacology and Physiology. Roč. 42, č. 5 (2015), s. 496-501. ISSN 0305-1870. E-ISSN 1440-1681
R&D Projects: GA ČR(CZ) GAP303/12/1162
Institutional support: RVO:67985823
Keywords : cardioprotection * chronic hypoxia * ischaemia/reperfusion * mitochondrial function * opioid receptors
Subject RIV: ED - Physiology
Impact factor: 2.004, year: 2015

Adaptation of rats to chronic continuous hypoxia protected their hearts against post-ischemic contractile dysfunction, decreased creatine kinase release and attenuated the depression of mitochondrial respiration and calcium retention capacity. All these beneficial effects were abolished by naloxone. It suggests that the preserved mitochondrial function contributes to the protected cardiac phenotype conferred by chronic hypoxia and points to an important role of opioid receptor activation
Permanent Link: http://hdl.handle.net/11104/0246809